Methyl iodide → HCID 86741220, compound

HRID 980471Notes

Reaction equation

HRID 980471 reaction equation
[Na].[S:2](=[C:5]([CH2:13][CH3:14])[CH2:6][C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1)(=[O:4])=[O:3].[CH3:15]I>>[CH3:15][N:11]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:6][C:5](=[S:2](=[O:4])=[O:3])[CH2:13][CH3:14])[CH2:12]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 86741221HCID 86741221, compound

Product 1

HCID 86741220HCID 86741220, compound

Procedure

3.2 g of 2-(2-sulfonylbutyl)pyrazine (900) was added to a solution of 10 ml methyl iodide/25 ml methanol and the mixture refluxed for 4 days. It was then concentrated and purified by gel permeation chromatography (Biogel P-2/water). Freeze-drying gave 2.9 g of an amorphous solid (1000) which was crystallized from ethyl acetate/propanol, m.p. 224°-5° (dec.). UV H2O max: 283 (3.88).

Workup

  1. temperaturethe mixture refluxed for 4 days
  2. concentrationIt was then concentrated
  3. custompurified by gel permeation chromatography (Biogel P-2/water)
  4. customFreeze-drying

Sources & evidence

ORD record
ord-83cb6239381e44399912cb9b7d122ee2
Source dataset
uspto-grants-1987_01
Patent number
US04638005

Reaction notes

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