Methyl iodide → HCID 86741220, compound

Participants

Reaction Steps

3.2 g of 2-(2-sulfonylbutyl)pyrazine (900) was added to a solution of 10 ml methyl iodide/25 ml methanol and the mixture refluxed for 4 days. It was then concentrated and purified by gel permeation chromatography (Biogel P-2/water). Freeze-drying gave 2.9 g of an amorphous solid (1000) which was crystallized from ethyl acetate/propanol, m.p. 224°-5° (dec.). UV H2O max: 283 (3.88).

Provenance & Evidence