Methyl iodide → HCID 86741228, compound

HRID 980478Notes

Reaction equation

HRID 980478 reaction equation
[Na].[S:2](=[CH:5][C:6]1[CH:11]=[N:10][CH:9]=[C:8]([CH3:12])[N:7]=1)(=[O:4])=[O:3].[CH3:13]I>>[CH3:13][N:10]1[CH:9]=[C:8]([CH3:12])[N:7]=[C:6]([CH:5]=[S:2](=[O:3])=[O:4])[CH2:11]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 86741229HCID 86741229, compound

Product 1

HCID 86741228HCID 86741228, compound

Procedure

4.0 g of 2-sulfonylmethyl-6-methylpyrazine sodium salt (2900) was added to a solution of 15 ml methyl iodide/30 ml methanol and the mixture refluxed for 4 days. It was then cooled and filtered. The solid was chromatographed (Biogel P-2/water) and freeze-dried to give 3.4 g of product (3000). It was recrystallized from propanol/water, m.p.>280° (dec.). UV H2O max: 288 (3.92).

Workup

  1. temperaturethe mixture refluxed for 4 days
  2. temperatureIt was then cooled
  3. filtrationfiltered
  4. customThe solid was chromatographed (Biogel P-2/water)
  5. customfreeze-dried

Sources & evidence

ORD record
ord-b0a506c3b1ee4111b9c50a6443a7980d
Source dataset
uspto-grants-1987_01
Patent number
US04638005

Reaction notes

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