Methyl iodide → HCID 86741230, compound

HRID 980479Notes

Reaction equation

HRID 980479 reaction equation
[Na].[S:2](=[CH:5][C:6]1[CH:11]=[N:10][C:9]([CH3:12])=[CH:8][N:7]=1)(=[O:4])=[O:3].[CH3:13]I>>[CH3:13][N:10]1[C:9]([CH3:12])=[CH:8][N:7]=[C:6]([CH:5]=[S:2](=[O:3])=[O:4])[CH2:11]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 86741231HCID 86741231, compound

Product 1

HCID 86741230HCID 86741230, compound

Procedure

2.0 g of 2-sulfonylmethyl-5-methylpyrazine sodium salt (3100) was added to a solution of 15 ml methyl iodide/25 ml methanol and refluxed for 5 days. The mixture was then cooled and filtered. The solid was purified by gel permeation chromatography (Biogel P-2/water) and freeze-dried to give 1.6 g of product (3200). It was recrystallized from propanol/water, m.p.>350° (dec.) UV H2O max: 213 (3.91), 293 (3.87).

Workup

  1. temperaturerefluxed for 5 days
  2. temperatureThe mixture was then cooled
  3. filtrationfiltered
  4. customThe solid was purified by gel permeation chromatography (Biogel P-2/water)
  5. customfreeze-dried

Sources & evidence

ORD record
ord-edf9ddd792ac4baba7861d85e460b77e
Source dataset
uspto-grants-1987_01
Patent number
US04638005

Reaction notes

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