Methyl iodide → HCID 20221646, compound

HRID 980481Notes

Reaction equation

HRID 980481 reaction equation
[N+:1]([C:4]([C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1)([CH3:6])[CH3:5])([O-:3])=[O:2].[CH3:13][I:14]>CO>[I-:14].[CH3:13][N+:11]1[CH:10]=[CH:9][N:8]=[C:7]([C:4]([N+:1]([O-:3])=[O:2])([CH3:5])[CH3:6])[CH:12]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20221594HCID 20221594, compound

Product 1

HCID 20221646HCID 20221646, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.0 g of 2-(1-nitroisopropyl)pyrazine (3600) was dissolved in 10 ml of methanol, 5 ml of methyl iodide added and the solution refluxed for 4 days. The solvent was removed and the residue was taken up in water and washed with chloroform. It was then chromatographed (Biogel P-2/water) and freeze-dried giving 3.2 g of product (3700). It was recrystallized from ethyl acetate/ethanol, m.p. 135°-6°. UV H2O max: 227 (4.18), 281 (3.89).

Workup

  1. temperaturethe solution refluxed for 4 days
  2. customThe solvent was removed
  3. washwashed with chloroform
  4. customIt was then chromatographed (Biogel P-2/water)
  5. customfreeze-dried

Sources & evidence

ORD record
ord-980cf0bce4f84039b73801cac7be87f7
Source dataset
uspto-grants-1987_01
Patent number
US04638005

Reaction notes

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