Methyl iodide → HCID 20221646, compound

Participants

Reaction Steps

2.0 g of 2-(1-nitroisopropyl)pyrazine (3600) was dissolved in 10 ml of methanol, 5 ml of methyl iodide added and the solution refluxed for 4 days. The solvent was removed and the residue was taken up in water and washed with chloroform. It was then chromatographed (Biogel P-2/water) and freeze-dried giving 3.2 g of product (3700). It was recrystallized from ethyl acetate/ethanol, m.p. 135°-6°. UV H2O max: 227 (4.18), 281 (3.89).

Provenance & Evidence