Methyl iodide → HCID 20221549, compound

HRID 980482Notes

Reaction equation

HRID 980482 reaction equation
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1)(=[O:3])[CH3:2].[CH3:13][I:14]>CCOCC>[I-:14].[CH3:13][N+:11]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:6][CH2:5][NH:4][C:1](=[O:3])[CH3:2])[CH:12]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20221598HCID 20221598, compound

Product 1

HCID 20221549HCID 20221549, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

3.0 g of 2-(2-acetamidoethyl)pyrazine, prepared by the method of G. M. Singerman, et. al., J. Org. Chem., 30, 4379 (1965), was dissolved in 10 ml of ether and 10 ml of methyl iodide added. The flask was stoppered and stored in the dark for 2 weeks. The resultant solid was filtered, washed with ether and dried in vacuo to give 3.4 g of a yellow solid product (3800). It was recrystallized from ethyl acetate/ethanol, m.p. 138°-9°. UV H2O max: 226 (4.17), 281 (3.85).

Workup

  1. waitstored in the dark for 2 weeks
  2. filtrationThe resultant solid was filtered
  3. washwashed with ether
  4. customdried in vacuo

Sources & evidence

ORD record
ord-88d53f916965435c9729669f8d89cef9
Source dataset
uspto-grants-1987_01
Patent number
US04638005

Reaction notes

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