Methyl iodide → HCID 20221549, compound

Participants

Reaction Steps

3.0 g of 2-(2-acetamidoethyl)pyrazine, prepared by the method of G. M. Singerman, et. al., J. Org. Chem., 30, 4379 (1965), was dissolved in 10 ml of ether and 10 ml of methyl iodide added. The flask was stoppered and stored in the dark for 2 weeks. The resultant solid was filtered, washed with ether and dried in vacuo to give 3.4 g of a yellow solid product (3800). It was recrystallized from ethyl acetate/ethanol, m.p. 138°-9°. UV H2O max: 226 (4.17), 281 (3.85).

Provenance & Evidence