Sodium → HCID 54285463, compound

HRID 980485Notes

Reaction equation

HRID 980485 reaction equation
C([O:4][CH:5]([CH2:14][O:15]C(=O)C)[CH:6]=[CH:7][C:8]1[CH:13]=[N:12][CH:11]=[CH:10][N:9]=1)(=O)C.[Na]>CO>[OH:4][CH:5]([CH2:14][OH:15])[CH:6]=[CH:7][C:8]1[CH:13]=[N:12][CH:11]=[CH:10][N:9]=1

Participants

4

Reactant 2

HCID 5360545SodiumHCID 54065281HCID 54065281, compound

Product 1

HCID 54285463HCID 54285463, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.60 g of 2-(3,4-diacetoxy-1-butenyl)pyrazine (4104) was added to a solution of 78 mg of sodium in 50 ml of methanol. This was stirred at 25° overnight and then concentrated in vacuo. The product was purified by gel permeation chromatography (Biogel P-2/water) and gave 1.71 g of 2-(3,4-dihydroxy-1-butenyl)pyrazine (4105) as a pale yellow oil. UV H2O max: 234 (4.08), 292 (3.86).

Workup

  1. concentrationconcentrated in vacuo
  2. customThe product was purified by gel permeation chromatography (Biogel P-2/water)

Sources & evidence

ORD record
ord-9a5b1575ea204391ab912474f479c375
Source dataset
uspto-grants-1987_01
Patent number
US04638005

Reaction notes

Loading…