Sulfuric Acid → 2-Amino-2,3-dimethylbutanamide

HRID 980547Notes

Reaction equation

HRID 980547 reaction equation
[NH2:1][C:2]([CH3:8])([CH:5]([CH3:7])[CH3:6])[C:3]#[N:4].S(=O)(=O)(O)[OH:10]>C1COCC1>[NH2:1][C:2]([CH3:8])([CH:5]([CH3:7])[CH3:6])[C:3]([NH2:4])=[O:10]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 943552-Amino-2,3-dimethylbutyronitrile

Product 1

HCID 97937732-Amino-2,3-dimethylbutanamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a similar way, hydrolysis of the (+)-2-amino-2,3-dimethylbutyronitrile with sulfuric acid yields the (-)-2-amino-2,3-dimethylbutyramide, mp 81°-82° C., [α]D25 =-57.14° (c=0.0654 g/ml THF).

Sources & evidence

ORD record
ord-4c4b65e3638d4a20bcb0d460b21acbe6
Source dataset
uspto-grants-1987_01
Patent number
US04638068

Reaction notes

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