Cyclopropylamine → Ethyl 4-[6-(cyclopropylamino)-3-nitro-2-pyridinyl]-1-piperazinecarboxylate

HRID 980731Notes

Reaction equation

HRID 980731 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]2)[C:5]([N+:19]([O-:21])=[O:20])=[CH:4][CH:3]=1.[N:22]12[CH2:32][CH2:31][CH2:30]N=C1CCCCC2.C1(N)CC1>C(O)C>[CH:32]1([NH:22][C:2]2[N:7]=[C:6]([N:8]3[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]3)[C:5]([N+:19]([O-:21])=[O:20])=[CH:4][CH:3]=2)[CH2:30][CH2:31]1

Participants

5

Reactant 3

HCID 69828CyclopropylamineHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 13076363Ethyl 4-(6-chloro-3-nitropyridin-2-yl)piperazine-1-carboxylate

Product 1

HCID 13565851Ethyl 4-[6-(cyclopropylamino)-3-nitro-2-pyridinyl]-1-piperazinecarboxylateYield 47.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 126.0 g (0.4 mole) of 4-(6-chloro-3-nitro-2-pyridinyl)-1-piperazinecarboxylic acid, ethyl ester (prepared as described in European Patent Publication No. 9425), 76.1 g (0.5 mole) of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), 28.6 g (0.5 mole) of cyclopropylamine and 500 ml of absolute ethanol was stirred at room temperature for 48 hours. The solution was then heated at reflux for four hours and concentrated in vacuo. The residue was partitioned between chloroform and water. The chloroform layer was dried over magnesium sulfate and concentrated in vacuo. The residue was triturated with ether to give 64.0 g of the title compound, mp 100°-103° C.

Workup

  1. temperatureThe solution was then heated
  2. temperatureat reflux for four hours
  3. concentrationconcentrated in vacuo
  4. customThe residue was partitioned between chloroform and water
  5. dry with materialThe chloroform layer was dried over magnesium sulfate
  6. concentrationconcentrated in vacuo
  7. customThe residue was triturated with ether

Sources & evidence

ORD record
ord-0136b1c5362e4a4eac41591252e45d14
Source dataset
uspto-grants-1987_01
Patent number
US04638067

Reaction notes

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