反应详情

温度

0 °C

Succinic anhydride (22.06 gm) was added to a mixture of 2,6-dimethylanisole (30 g) and anhydrous aluminium trichloride (59 g) in 1,2-dichloroethane (200 ml) at 0° C. The mixture was stirred for 0.5 hr at 0° C. and at room temperature for 4 hr. The mixture was poured onto ice-concentrated hydrochloric acid. After stirring vigorously for 5 min, the mixture was extracted with ethyl acetate. The dried (MgSO4) organic fraction was evaporated to give 4-(3,5-dimethyl-4-methoxyphenyl)-4-oxobutyric acid as white crystals, mp 108° C.

1. additionThe mixture was poured onto ice-concentrated hydrochloric acid
2. stirringAfter stirring vigorously for 5 min
3. extractionthe mixture was extracted with ethyl acetate
4. dry with materialThe dried (MgSO4) organic fraction
5. customwas evaporated