Triethylamine → HCID 131714667, compound

HRID 980804Notes

Reaction equation

HRID 980804 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[Cl:6][CH2:7][CH2:8][CH2:9][O:10][C:11]12[CH:20]=[CH:19][CH:18]=[CH:17][CH:12]1[CH2:13][CH:14]2[CH2:15][OH:16].C(N(CC)CC)C>C(Cl)Cl>[S:2]([OH:4])(=[O:10])(=[O:3])[CH3:1].[Cl:6][CH2:7][CH2:8][CH2:9][O:10][C:11]12[CH:20]=[CH:19][CH:18]=[CH:17][CH:12]1[CH2:13][CH:14]2[CH2:15][OH:16]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 131714668HCID 131714668, compound

Product 1

HCID 131714667HCID 131714667, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methane sulfonylchloride (1.13 g) is added dropwise to a stirred solution of 3-(3-chloropropoxy)-1-hydroxymethylbenzocyclobutene (1.83 g) and triethylamine (1.58 ml) in methylene chloride (32 ml) at 5° C. under nitrogen. The reaction mixture is stirred at RT for about 2 hours, washed with water, saturated NaCl, dried over Na2SO4, filtered and evaporated in vacuo yielding the desired product as an oil.

Workup

  1. washwashed with water, saturated NaCl
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-b23aef7cf22e4c7ab663ff5c83719f25
Source dataset
uspto-grants-1987_01
Patent number
US04639442

Reaction notes

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