Hydrochloric Acid → HCID 13231137, compound

HRID 980822Notes

Reaction equation

HRID 980822 reaction equation
C([S:4][CH:5]([CH3:23])[C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]([CH3:22])[CH2:17][C:18](=[O:21])[NH:19][N:20]=2)=[CH:11][CH:10]=1)=[O:7])(=O)C.[OH-].[Na+].Cl>CO>[SH:4][CH:5]([CH3:23])[C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:16]([CH3:22])[CH2:17][C:18](=[O:21])[NH:19][N:20]=2)=[CH:13][CH:14]=1)=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22160502HCID 22160502, compound

Product 1

HCID 13231137HCID 13231137, compoundYield 85.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 20 ml of methanol was dissolved 1.0 g of the compound obtained in Example 31. To this solution was added in a stream of nitrogen 10 ml of 1N caustic soda solution, and the mixture was reacted for 90 minutes at room temperature. The mixture was made acidic by the addition of 6-N hydrochloric acid to precipitate crystals, which were then collected by filtration and washed with methanol to obtain 750 mg of the end product. M.P. 236°-237° C. (uncorrected).

Workup

  1. customthe mixture was reacted for 90 minutes at room temperature
  2. customto precipitate crystals, which
  3. filtrationwere then collected by filtration
  4. washwashed with methanol

Sources & evidence

ORD record
ord-29303661a6f54ce6938d5aeca7eebbd3
Source dataset
uspto-grants-1987_01
Patent number
US04639451

Reaction notes

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