Isopropanol → HCID 86741242, compound

HRID 980880Notes

Reaction equation

[NH2:1][C:2]1[C:7](C(O)=O)=[CH:6][C:5]([O:11][CH3:12])=[C:4]([O:13][CH3:14])[CH:3]=1.[O-][C:16]#[N:17].[K+].[OH-].[Na+].[CH:21](O)(C)C.[C:25]([OH:29])(=[O:28])[CH:26]=[CH2:27]>C(O)(=O)C.O>[CH3:14][O:13][C:4]1[C:5]([O:11][CH3:12])=[CH:6][CH:7]=[C:2]2[C:3]=1[CH:21]=[N:17][CH2:16][N:1]2[CH2:27][CH2:26][C:25]([OH:29])=[O:28]

Participants

Conditions

Temperature: 60 °C

Procedure

6-Amino-3,4-dimethoxybenzoic acid (5.5 g, 27.8 m) in glacial acetic acid (100 ml) and acrylic acid (4 ml) was refluxed for 18 hours. Potassium cyanate (5.6 g, 28.4 mM) in H2O (132 ml) was added gradually and stirred for 2 hours at 60° C. After cooling the reaction mixture to 20° C., sodium hydroxide pellets (40 g, 1.0 mole) were added while maintaining the temperature below 60° C. The reaction mixture was then heated at 90° C. for 45 minutes. Upon cooling in an ice bath, the sodium salt of the product precipitated, was filtered, resuspended in H2O (60 ml), acidified (pH 3.0) with concentrated HCl, cooled, and filtered to give the crude product. Trituration with warm isopropanol afforded 2.2 g (25.6%) of the desired product which melted at 226°-228° C.

Workup

temperatureAfter cooling the reaction mixture to 20° C.
temperaturewhile maintaining the temperature below 60° C
temperatureThe reaction mixture was then heated at 90° C. for 45 minutes
temperatureUpon cooling in an ice bath
customthe sodium salt of the product precipitated
filtrationwas filtered
temperaturecooled
filtrationfiltered
customto give the crude product

Sources & evidence

ORD record: ord-1376b27bbab94bde89573c468e52d830
Source dataset: uspto-grants-1987_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04639518

Reaction notes

Loading…