5-Aminopentan-1-ol → HCID 12783829, compound

HRID 980896Notes

Reaction equation

HRID 980896 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]2[C:10](=[O:17])[NH:11][C:12](SC)=[N:13][CH:14]=2)=[CH:4][CH:3]=1.[NH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][OH:24]>>[OH:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][NH:18][C:12]1[NH:11][C:10](=[O:17])[C:9]([CH2:8][C:5]2[CH:6]=[N:7][C:2]([CH3:1])=[CH:3][CH:4]=2)=[CH:14][N:13]=1

Participants

3

Reactant 2

HCID 756345-Aminopentan-1-olHCID 127838272-methylthio-5-(2-methylpyrid-5-ylmethyl)-1H-pyrimid-4-one

Product 1

HCID 12783829HCID 12783829, compound

Procedure

Reaction of 5-(6-methyl-3-pyridylmethyl)-2-methylthio-4-pyrimidone with 5-aminopentanol at 170°-180° gave 2-(5-hyroxypentylamino)-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone which was isolated as the dihydrochloride salt m.p. 215°-217°.

Sources & evidence

ORD record
ord-bd39fdee6634474395236e68672273b9
Source dataset
uspto-grants-1987_01
Patent number
US04639519

Reaction notes

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