Methyl Isocyanate → HCID 20221250, compound

HRID 980903Notes

Reaction equation

HRID 980903 reaction equation
[CH2:1]([C:4]1[S:5][C:6]([NH2:9])=[N:7][N:8]=1)[CH2:2][CH3:3].[CH3:10][N:11]=[C:12]=[O:13]>CN(C)C=O>[CH2:1]([C:4]1[S:5][C:6]([NH:9][C:12]([NH:11][CH3:10])=[O:13])=[N:7][N:8]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 5753945-Propyl-1,3,4-thiadiazol-2-amine

Product 1

HCID 20221250HCID 20221250, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To 14.9 g (0.1 mol) 2-n-propyl-5-amino-1,3,4-thiadiazole dissolved in 100 ml dimethyl formamide there are added dropwise, at 20° C., 5.7 g (0.1 mol) methyl isocyanate. After the subsidence of the heat effect, stirring is continued for 1 hour at 50° C., and distillation to one half of the original volume is then effected in a vacuum, followed by pouring into 400 ml of water. The crude N-(2-n-propyl-1,3,4-thiadiazol-5-yl)-N'-methyl urea (13) is obtained in solid form and is filtered off with suction.

Workup

  1. additionthere are added dropwise, at 20° C.
  2. distillationdistillation to one half of the original volume
  3. additionby pouring into 400 ml of water

Sources & evidence

ORD record
ord-594b8f163b834db8af298308f43cec69
Source dataset
uspto-grants-1987_01
Patent number
US04639526

Reaction notes

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