HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → 4-Cyano-2,3,5,6,7,8-hexahydro-7-methoxy-1-methyl-3-oxoisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-Acetyl-4-methoxycyclohexanone | HCID 13632724 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Cyano-2,3,5,6,7,8-hexahydro-7-methoxy-1-methyl-3-oxoisoquinoline | HCID 13632726 | 35% |
Reaction Steps
2-Acetyl-4-methoxycyclohexanone (1.02 g) and cyanoacetamide (0.462 g) were added to 5 ml of ethanol. After adding a small amount of piperidine, the mixture was heated under reflux for 2 hours. Deposited crystals were filtered out and recrystallized from methanol. There was obtained 0.42 g of 4-cyano-2,3,5,6,7,8-hexahydro-7-methoxy-1-methyl-3-oxoisoquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04639521 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-f3812168773e45588c957914eb8c6d0b |
| Source note | uspto-grants-1987_01 |