反应详情

2-Acetyl-4-methoxycyclohexanone (1.02 g) and cyanoacetamide (0.462 g) were added to 5 ml of ethanol. After adding a small amount of piperidine, the mixture was heated under reflux for 2 hours. Deposited crystals were filtered out and recrystallized from methanol. There was obtained 0.42 g of 4-cyano-2,3,5,6,7,8-hexahydro-7-methoxy-1-methyl-3-oxoisoquinoline.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 2 hours
3. filtrationDeposited crystals were filtered out
4. customrecrystallized from methanol