HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → 3-Hydroxy-1-methyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-Acetylcyclohexanone | HCID 13400 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Hydroxy-1-methyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile | HCID 1389675 | 67% |
Reaction Steps
2-Acetylcyclohexanone (5 g) and cyanoacetamide (3 g) were added to 25 ml of ethanol and a small amount of piperidine was also added. The mixture was heated under reflux for 2 hours. After cooling, deposited crystals were filtered out and washed with ethanol. There was obtained 4.5 g of 4-cyano-2,3,5,6,7,8-hexahydro-1-methyl-3-oxoisoquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04639521 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-3b01498f39554ec9a6a3f9b04dfcebb3 |
| Source note | uspto-grants-1987_01 |