反应详情

2-Acetylcyclohexanone (5 g) and cyanoacetamide (3 g) were added to 25 ml of ethanol and a small amount of piperidine was also added. The mixture was heated under reflux for 2 hours. After cooling, deposited crystals were filtered out and washed with ethanol. There was obtained 4.5 g of 4-cyano-2,3,5,6,7,8-hexahydro-1-methyl-3-oxoisoquinoline.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 2 hours
3. temperatureAfter cooling
4. filtrationdeposited crystals were filtered out
5. washwashed with ethanol