Toluene → 2,3-Dihydro-2,2-dimethyl-7-benzofuranol

HRID 980923Notes

Reaction equation

HRID 980923 reaction equation
[OH:1][C:2](C)([CH3:12])[CH2:3]OC1C=CC=CC=1O.C1(C)C=CC(S(O)(=O)=[O:21])=CC=1.[C:25]1([CH3:31])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH3:3][C:2]1([CH3:12])[O:1][C:26]2[C:27]([OH:21])=[CH:28][CH:29]=[CH:30][C:25]=2[CH2:31]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 6101p-Toluenesulfonic acidHCID 13827591HCID 13827591, compound

Product 1

HCID 152782,3-Dihydro-2,2-dimethyl-7-benzofuranol

Conditions

Temperature
111 °C

Procedure

Preferably, in this step, the intermediate 2-(2-hydroxy-2-methylpropoxy)phenol is combined with para-toluensulfonic acid and toluene and heated to reflux (approximately 111° C.) to produce carbofuran phenol.

Workup

  1. temperatureheated

Sources & evidence

ORD record
ord-1c173c713d9d4180b01d25d41d1dd095
Source dataset
uspto-grants-1987_01
Patent number
US04639536

Reaction notes

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