反应详情

温度

20 °C

To a suspension of 84 g of methyl 2-[(aminosulfonyl)methyl]benzoate in 300 ml of absolute ethanol was added dropwise 22 g of hydrazine monohydrate. The thick suspension was heated at reflux for about 16 hours to yield a solution, then a thick suspension, at reflux temperature. The suspension was cooled to 20° C., filtered, and the residue was washed 1×100 ml of water and suction dried about three hours to provide 49 g of the subject compound; m.p. 221°-222° C.

1. temperatureThe thick suspension was heated
2. temperatureat reflux for about 16 hours
3. customto yield a solution
4. temperaturea thick suspension, at reflux temperature
5. filtrationfiltered
6. washthe residue was washed 1×100 ml of water and suction
7. customdried about three hours