Methylamine → 2-(4-Methyl-2H-phthalazin-1-on-2-yl)-N-methylethylamine hydrobromide

HRID 981022Notes

Reaction equation

HRID 981022 reaction equation
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[N:4]([CH2:13][CH2:14][Br:15])[N:3]=1.[CH3:16][NH2:17]>C(O)C>[BrH:15].[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[N:4]([CH2:13][CH2:14][NH:17][CH3:16])[N:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 217614862-(2-Bromoethyl)-4-methylphthalazin-1(2H)-one

Product 1

HCID 198989332-(4-Methyl-2H-phthalazin-1-on-2-yl)-N-methylethylamine hydrobromide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(4-Methyl-2H-phthalazin-1-on-2-yl)ethyl bromide (6.1 g) and methylamine (20 ml of 30% ethanolic methylamine) in ethanol (150 ml) were heated in a bomb at 100° for 2 hours. The solvent was removed and the residue triturated with ethyl acetate to give a yellow solid, which was recrystallised from ethanol to afford the title compound, yield 5.03 g, m.p. 219°-221°.

Workup

  1. customThe solvent was removed
  2. customthe residue triturated with ethyl acetate
  3. customto give a yellow solid, which
  4. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-0bbadcf4dd9a4c6fb3f96ae94d9084ce
Source dataset
uspto-grants-1991_02
Patent number
US04990509

Reaction notes

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