反应详情

To a stirred solution of imidazopyridine (540 mg, 4.5 mmol) in dimethylacetamide (100 mL) under argon, the product of Example D (1.6 g,) was added in one portion. The reaction temperature was slowly raised to 80°-85° C. and was stirred for 60 h. The reaction flask was cooled to room temperature and the solvent was removed under reduced pressure at <45° C. The residue obtained was triturated with excess of dry ether and filtered.

1. temperatureThe reaction temperature was slowly raised to 80°-85° C.
2. customthe solvent was removed under reduced pressure at <45° C
3. customThe residue obtained
4. customwas triturated with excess of dry ether
5. filtrationfiltered