HRID981222

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4837

Piperazine

C4H10N2

结构：O=C(O)c1cn(C2CC2)c2nc3cc(Cl)c(F)cc3cc2c1=O

HCID14700556

未命名化合物

PRODUCTS

生成物

结构：O=C(O)c1cn(C2CC2)c2nc3cc(N4CCNCC4)c(F)cc3cc2c1=O

HCID14700573

未命名化合物

结构：O.O.O=C(O)c1cn(C2CC2)c2nc3cc(N4CCNCC4)c(F)cc3cc2c1=O

HCID67925866

未命名化合物

收率 190.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

1-Cyclopropyl-7-fluoro-4-oxo-8-(1-piperazinyl)-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid is prepared under the conditions of Reference Example 5 but starting from 1 g of 8-chloro-1-cyclopropyl-7-fluoro-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid and 2.6 g of piperazine in 10 cm3 of pyridine. 0.6 g of 1-cyclopropyl-7-fluoro-4-oxo-8-(1-piperazinyl)-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid dihydrate is obtained in the form of a yellow solid melting at 342°-343° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fc40555437f34d9290ae651728fcfd61
来源数据集: uspto-grants-1991_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04990515
来源说明: uspto-grants-1991_02

反应 SMILES

Cl[C:2]1[C:3]([F:23])=[CH:4][C:5]2[C:6]([CH:22]=1)=[N:7][C:8]1[N:9]([CH:19]3[CH2:21][CH2:20]3)[CH:10]=[C:11]([C:16]([OH:18])=[O:17])[C:12](=[O:15])[C:13]=1[CH:14]=2.[NH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>N1C=CC=CC=1>[CH:19]1([N:9]2[C:8]3[N:7]=[C:6]4[CH:22]=[C:2]([N:24]5[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]5)[C:3]([F:23])=[CH:4][C:5]4=[CH:14][C:13]=3[C:12](=[O:15])[C:11]([C:16]([OH:18])=[O:17])=[CH:10]2)[CH2:21][CH2:20]1.[OH2:15].[OH2:15].[CH:19]1([N:9]2[C:8]3[N:7]=[C:6]4[CH:22]=[C:2]([N:24]5[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]5)[C:3]([F:23])=[CH:4][C:5]4=[CH:14][C:13]=3[C:12](=[O:15])[C:11]([C:16]([OH:18])=[O:17])=[CH:10]2)[CH2:21][CH2:20]1