1-Methylpiperazine → HCID 20063292, compound

HRID 981235Notes

Reaction equation

HRID 981235 reaction equation
Cl[C:2]1[C:3]([F:23])=[CH:4][C:5]2[C:6]([CH:22]=1)=[N:7][C:8]1[N:9]([CH2:19][CH2:20][F:21])[CH:10]=[C:11]([C:16]([OH:18])=[O:17])[C:12](=[O:15])[C:13]=1[CH:14]=2.[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>N1C=CC=CC=1>[F:23][C:3]1[C:2]([N:28]2[CH2:29][CH2:30][N:25]([CH3:24])[CH2:26][CH2:27]2)=[CH:22][C:6]2=[N:7][C:8]3[N:9]([CH2:19][CH2:20][F:21])[CH:10]=[C:11]([C:16]([OH:18])=[O:17])[C:12](=[O:15])[C:13]=3[CH:14]=[C:5]2[CH:4]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 20063275HCID 20063275, compound

Product 1

HCID 20063292HCID 20063292, compoundYield 42.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A suspension of 1.2 g of 8-chloro-7-fluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid in 12 cm3 of pyridine and 3.52 g of 1-methylpiperazine is heated, with stirring, at a temperature close to 110° C. for 6 hours. After treatment under the conditions described in Reference Example 3, 0.6 g of 7-fluoro-1-(2-fluoroethyl)-8-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid is obtained in the form of a yellow solid melting at 306°-308° C.

Workup

  1. temperatureis heated
  2. customclose to 110° C. for 6 hours

Sources & evidence

ORD record
ord-db5d5e19429646b8a81c9d7be5600a93
Source dataset
uspto-grants-1991_02
Patent number
US04990515

Reaction notes

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