1-Phenylpiperazine → HCID 18643655, compound

HRID 981391Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][C@H:9]([C:14]([OH:16])=O)[CH2:10][C:11](=[O:13])[NH2:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:17]1([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:1]([O:5][C:6]([NH:8][C@H:9]([C:14]([N:26]1[CH2:27][CH2:28][N:23]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:24][CH2:25]1)=[O:16])[CH2:10][C:11](=[O:13])[NH2:12])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 70961-Phenylpiperazine

HCID 82035N2-((tert-Butoxy)carbonyl)-L-asparagine

Product 1

HCID 18643655HCID 18643655, compoundYield 136.3%

Procedure

In the same manner as in Reference Example 2, N-tert-butoxycarbonyl-L-asparagine (4.3 g) and 1-phenylpiperazine (4.3 g) were condensed to obtain colorless powder 1-(N-tert-butoxycarbonyl-L-asparaginyl)-4-phenylpiperazine (9.5 g).

Workup

customcondensed

Sources & evidence

ORD record: ord-a23f70702baf41f6a2084ba100d097ef
Source dataset: uspto-grants-1991_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04990614

Reaction notes

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