1-Methylpiperazine → HCID 18643654, compound

HRID 981392Notes

Reaction equation

HRID 981392 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]([C:14]([OH:16])=O)[CH2:10][C:11](=[O:13])[NH2:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[C:1]([O:5][C:6]([NH:8][C@H:9]([C:14]([N:21]1[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]1)=[O:16])[CH2:10][C:11](=[O:13])[NH2:12])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 82035N2-((tert-Butoxy)carbonyl)-L-asparagine

Product 1

HCID 18643654HCID 18643654, compoundYield 81.3%

Procedure

In the same manner as in Reference Example 2, N-tert-butoxycarbonyl-L-asparagine (5.0 g) and 1-methylpiperazine (2.2 g) were condensed to obtain colorless crystal 1-(N-tert-butoxycarbonyl-L-asparaginyl)-4-methylpiperazine (5.5 g).

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-5231b46dc2da4dd6b4807c9be4b96a4a
Source dataset
uspto-grants-1991_02
Patent number
US04990614

Reaction notes

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