HCID 18643597, compound → HCID 18643590, compound

HRID 981395Notes

Reaction equation

HRID 981395 reaction equation
C([O:8][C:9]1[CH:37]=[C:36]([O:38]CC2C=CC=CC=2)[CH:35]=[CH:34][C:10]=1[C:11]([NH:13][C@H:14]([C:20]([N:22]1[CH2:27][CH2:26][N:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:24][CH2:23]1)=[O:21])[CH2:15][CH2:16][C:17](=[O:19])[NH2:18])=[O:12])C1C=CC=CC=1>[H][H].[C].[Pd]>[OH:8][C:9]1[CH:37]=[C:36]([OH:38])[CH:35]=[CH:34][C:10]=1[C:11]([NH:13][C@H:14]([C:20]([N:22]1[CH2:27][CH2:26][N:25]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:24][CH2:23]1)=[O:21])[CH2:15][CH2:16][C:17](=[O:19])[NH2:18])=[O:12]

Participants

4

Reactant 1

HCID 18643597HCID 18643597, compound

Product 1

HCID 18643590HCID 18643590, compoundYield 66.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 178418361HCID 178418361, compoundSolvent

Procedure

10% Palladium-carbon (120 mg) was added to an ethanolic solution (20 ml) of 1-(2,4-dibenzyloxybenzoyl-L-glutaminyl)-4-phenylpiperazine (364 mg) and catalytic reduction was carried out for 6 hours at room temperature and under atmospheric pressure in hydrogen stream. Thereafter, treatments were effected in the same manner as in Example 5 (ii) to obtain powdery 1-(2,4-dihydroxybenzoyl-L-glutaminyl)-4-phenylpiperazine (169 mg).

Sources & evidence

ORD record
ord-30b4660e83a34b9bb53ad36a969bb7cb
Source dataset
uspto-grants-1991_02
Patent number
US04990614

Reaction notes

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