Putrescine → 3-((4-Aminobutyl)amino)propanenitrile

HRID 981417Notes

Reaction equation

HRID 981417 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][NH2:6].[C:7](#[N:10])[CH:8]=[CH2:9]>>[C:7]([CH2:8][CH2:9][NH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH2:6])#[N:10]

Participants

3

Reactant 2

HCID 1045PutrescineHCID 7855Acrylonitrile

Product 1

HCID 125483743-((4-Aminobutyl)amino)propanenitrileYield 48.7%

Procedure

To 1,4-diaminobutane (84.6 g) cooled on ice is added dropwise acrylonitrile(50.9 g). After dropping is over, the reaction solution is stirred for 20 minutes under ice cooling, followed by stirring at 40° C. for one hour and then at 100° C. for three hours. The product is distilled under reduced pressure and purified to yield 1-(N-2-cyano-ethyl)amino-4-aminobutane (66 g) in the colorless oily form.

Workup

  1. stirringby stirring at 40° C. for one hour
  2. waitat 100° C. for three hours
  3. distillationThe product is distilled under reduced pressure
  4. custompurified

Sources & evidence

ORD record
ord-44f6b8dfc7d44019b8cb899ed38aca9a
Source dataset
uspto-grants-1991_02
Patent number
US04990511

Reaction notes

Loading…