Putrescine → 3-((4-Aminobutyl)amino)propanenitrile

Participants

Reaction Steps

To 1,4-diaminobutane (84.6 g) cooled on ice is added dropwise acrylonitrile(50.9 g). After dropping is over, the reaction solution is stirred for 20 minutes under ice cooling, followed by stirring at 40° C. for one hour and then at 100° C. for three hours. The product is distilled under reduced pressure and purified to yield 1-(N-2-cyano-ethyl)amino-4-aminobutane (66 g) in the colorless oily form.

Provenance & Evidence