HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 981506Generated: October 30, 2026
1,2-Diaminocyclohexane, cis- → HCID 54131792, compound
https://huagongshe.com/reaction/981506
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Diaminocyclohexane, cis- | HCID 342917 | — |
| Reactant | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 54131792 | HCID 54131792 | 60.5% |
Reaction Steps
A mixture of 1.33 g of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 1.73 g of cis-1,2-diaminocyclohexane in 10 ml of pyridine was heated in an oil bath of 115° C. for 1 hour then filtered while hot. Cooling the filtrate afforded 1.09 g of the desired product, m.p. 270°-274° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04992449 |
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| Source dataset | uspto-grants-1991_02 |
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| ORD ID | ord-6667ac2c469c4065be003476bebf28d4 |
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| Source note | uspto-grants-1991_02 |
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