反应详情

温度

0 °C

Lithium aluminum hydride (2.5 g) was suspended in tetrahydrofuran (40 ml). Ethyl 2-(2-propylimidazol-1-yl)propanate [9.2 g] in tetrahydrofuran (40 ml) was added with stirring at 0° C. The reaction was refluxed for 3 hours, cooled to 0° C., water (3 ml) was added dropwise followed by 15% sodium hydroxide (3 ml) and a further portion of water (9 ml). The suspension was filtered through solka-flok and the solvent removed under reduced pressure. Dichloromethane (50 ml) was added, the organic phase washed with brine (25 ml) dried over magnesium sulphate and the solvent removed under reduced pressure yielding the title compound as a white foam 5.4 g (67%).

1. temperatureThe reaction was refluxed for 3 hours
2. temperaturecooled to 0° C.
3. filtrationThe suspension was filtered through solka-flok and the solvent
4. customremoved under reduced pressure
5. additionDichloromethane (50 ml) was added
6. washthe organic phase washed with brine (25 ml)
7. dry with materialdried over magnesium sulphate
8. customthe solvent removed under reduced pressure