HCID 20070371, compound → 1-Propanol, 2-[(2-aminophenyl)amino]-2-methyl-

HRID 981525Notes

Reaction equation

HRID 981525 reaction equation
[CH3:1][C:2]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-])=O)([CH3:5])[CH2:3][OH:4]>C(O)C.[Pd]>[CH3:5][C:2]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[NH2:13])([CH3:1])[CH2:3][OH:4]

Participants

4

Reactant 1

HCID 20070371HCID 20070371, compound

Product 1

HCID 119615571-Propanol, 2-[(2-aminophenyl)amino]-2-methyl-Yield 98%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-(1,1-dimethyl-2-hydroxyethyl)aminonitrobenzene (10 g) in ethanol (200 ml) was hydrogenated at 50p.s.i. (345 kPa) over 5% Pd/C (0.5 g) for 2 hours. The catalyst was filtered off and the solvent removed under reduced pressure yielding the title compound as a yellow foam 8.4 g (98%).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-cdeb9fdeb99742dfa3c8a0d9568cd911
Source dataset
uspto-grants-1991_02
Patent number
US04992447

Reaction notes

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