Hydrochloric Acid → HCID 178526669, compound

HRID 981576Notes

Reaction equation

HRID 981576 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][C:16]=1[O:17]C)[CH2:7][N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[SH:13])([O-:3])=[O:2].Cl>[OH-].[Na+]>[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][C:16]=1[OH:17])[CH2:7][N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[SH:13])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178490801HCID 178490801, compound

Product 1

HCID 178526669HCID 178526669, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of 1-[3'-nitro-4'-methoxybenzyl]-2mercaptoimidazole (1.59 g, 6.0 moles) in 10% aqueous NaOH (200 ml) was refluxed for two hours, cooled, acidified with concentrated HCl, cooled and filtered. The crystalline product was washed with water. Recrystallization from ethanol provided 1.25 g (80%) of product as yellow prisms: mp 225-227° (dec).

Workup

  1. temperaturecooled
  2. temperaturecooled
  3. filtrationfiltered
  4. washThe crystalline product was washed with water
  5. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-a1505d89cc864e6c983beac068d036b6
Source dataset
uspto-grants-1991_02
Patent number
US04992459

Reaction notes

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