HCID 178491902, compound → HCID 178516187, compound

HRID 981577Notes

Reaction equation

HRID 981577 reaction equation
[Cl:1][C:2]1[CH:14]=[C:13]([O:15]C)[CH:12]=[C:11]([Cl:17])[C:3]=1[CH2:4][N:5]1[CH:9]=[CH:8][N:7]=[C:6]1[SH:10]>Br>[Cl:17][C:11]1[CH:12]=[C:13]([OH:15])[CH:14]=[C:2]([Cl:1])[C:3]=1[CH2:4][N:5]1[CH:9]=[CH:8][N:7]=[C:6]1[SH:10]

Participants

3

Reactant 1

HCID 178491902HCID 178491902, compound

Product 1

HCID 178516187HCID 178516187, compoundYield 67.3%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A mixture of 1-[2',6'-dichloro-4'-methoxybenzyl]2-mercaptoimidazole (1 g) in concentrated aqueous hydrobromic acid (50 ml) was heated at reflux under argon for 1.25 hr, and then cooled. The product was collected by filtration. Washing with concentrated aqueous hydrobromic acid and water and drying yielded 0.64 g (60%) of product as light yellow crystals: mp 235° (dec).

Workup

  1. temperaturewas heated
  2. temperatureat reflux under argon for 1.25 hr
  3. temperaturecooled
  4. filtrationThe product was collected by filtration
  5. washWashing with concentrated aqueous hydrobromic acid and water
  6. customdrying

Sources & evidence

ORD record
ord-9f8efbe1adcb4115abd14757632c12d3
Source dataset
uspto-grants-1991_02
Patent number
US04992459

Reaction notes

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