Methylamine → 3-(4-Fluorophenyl)-5-isopropyl-1-methyl-2-phenyl-pyrrole

Participants

Reaction Steps

2.98 g (10 mmol) of 2-(4-fluorophenyl)-5-methyl1-phenyl-hexane-1,4-dione (Example 2) are heated at 80° C. in 10 ml of 40% strength aqueous methylamine solution, and about 14 ml of ethanol are added so that a clear solution forms. The solution is heated under reflux for a further 30 minutes and, after cooling, the precipitate is filtered off with suction. This is washed with a little ethanol and dried over phosphorus pentoxide in a vacuum desiccator.

Provenance & Evidence