反应详情

2.98 g (10 mmol) of 2-(4-fluorophenyl)-5-methyl1-phenyl-hexane-1,4-dione (Example 2) are heated at 80° C. in 10 ml of 40% strength aqueous methylamine solution, and about 14 ml of ethanol are added so that a clear solution forms. The solution is heated under reflux for a further 30 minutes and, after cooling, the precipitate is filtered off with suction. This is washed with a little ethanol and dried over phosphorus pentoxide in a vacuum desiccator.

1. additionare added so that a clear solution forms
2. temperatureThe solution is heated
3. temperatureunder reflux for a further 30 minutes
4. temperatureafter cooling
5. filtrationthe precipitate is filtered off with suction
6. washThis is washed with a little ethanol
7. dry with materialdried over phosphorus pentoxide in a vacuum desiccator