Triethylamine → HCID 14330455, compound

HRID 981669Notes

Reaction equation

HRID 981669 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][CH2:10][C:11](=[CH2:15])[C:12]([OH:14])=[O:13].C(N(CC)CC)C>ClC1C=CC=CC=1Cl>[CH3:1][O:2][C:3]1[C:4]2[S:9][CH2:10][CH:11]([C:12]([OH:14])=[O:13])[CH2:15][C:5]=2[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 14330452HCID 14330452, compound

Product 1

HCID 14330455HCID 14330455, compound

Reagents, catalysts & solvents 1

HCID 72391,2-DichlorobenzeneSolvent

Procedure

A mixture of 22.5 g of α-(o-methoxyphenylthio-methyl)-acrylic acid, 2.53 g of triethylamine and 200 ml o-dichlorobenzene is heated for 12 hours at 195°. After dilution with ether the products are extracted with sodium bicarbonate solution. Acidification of the basic extracts affords 8-methoxy-3,4-dihydro-2H-[1]-benzothiopyran-3-carboxylic acid, m.p. 223°-226°.

Workup

  1. temperatureis heated for 12 hours at 195°
  2. extractionAfter dilution with ether the products are extracted with sodium bicarbonate solution

Sources & evidence

ORD record
ord-2efe18000fdf40b0a32e164ec1eb44a1
Source dataset
uspto-grants-1991_02
Patent number
US04992465

Reaction notes

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