反应详情

The diisopropyl ethylmalate (diastereoisomeric mixture) prepared as described above is saponified in aqueous dioxane with potassium hydroxide at the reflux temperature. The diacid is recovered by passing the cooled reaction mixture over Dowex resin (sulfonic acid form) and evaporating the eluate.

1. customThe diacid is recovered
2. customthe cooled reaction mixture over Dowex resin (sulfonic acid form)
3. customevaporating the eluate