Potassium Hydroxide → Ethylmalic acid monomethyl ester

Participants

Reaction Steps

The diisopropyl ethylmalate (diastereoisomeric mixture) prepared as described above is saponified in aqueous dioxane with potassium hydroxide at the reflux temperature. The diacid is recovered by passing the cooled reaction mixture over Dowex resin (sulfonic acid form) and evaporating the eluate.

Provenance & Evidence