2-Mercaptoethanol → 2-{[2-(2-Hydroxyethanesulfonyl)-4-nitrophenyl]sulfanyl}ethan-1-ol

HRID 981810Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 981810
C(=O)([O-])[O-].[K+].[K+].[OH:7][CH2:8][CH2:9][S:10]([C:13]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[CH:15][C:14]=1Cl)(=[O:12])=[O:11].[SH:23][CH2:24][CH2:25][OH:26]>O>[OH:7][CH2:8][CH2:9][S:10]([C:13]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[CH:15][C:14]=1[S:23][CH2:24][CH2:25][OH:26])(=[O:12])=[O:11]

Komponenten

5

Edukt 3

HCID 15672-MercaptoethanolHCID 11430Potassium CarbonateHCID 136286432-Chloro-5-nitrophenyl hydroxyethyl sulfone

Produkt 1

HCID 136286502-{[2-(2-Hydroxyethanesulfonyl)-4-nitrophenyl]sulfanyl}ethan-1-olAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

58.75 g of potassium carbonate are added at 22° C. to a suspension of 132.85 g of 2-chloro-5-nitrophenyl hydroxyethyl sulfone in 100 ml of water and 80 g of 2-mercaptoethanol in the course of 1.5 hours, and the mixture is stirred at room temperature for 4 hours. The reaction mixture is then filtrated with suction, and the filter residue is washed with water until neutral. Drying these gives 124.3 g of 2-β-hydroxyethylmercapto-5-nitrophenyl hydroxyethyl sulfone having a melting point of 116°-118° C. (purity about 99%), which corresponds to a yield of 81% of theory, relative to starting 2-chloro-5-nitrophenyl hydroxyethyl sulfone.

Aufarbeitung

  1. filtrationThe reaction mixture is then filtrated with suction
  2. washthe filter residue is washed with water until neutral
  3. dry with materialDrying these gives 124.3 g of 2-β-hydroxyethylmercapto-5-nitrophenyl hydroxyethyl sulfone having a melting point of 116°-118° C. (purity about 99%), which

Quellen und Nachweise

ORD-Eintrag
ord-41ae229936a0446481a92474317ed0a5
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04992589

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