HCID 20068637, compound → HCID 15723691, compound

Participants

Reaction Steps

α-[(4-Nitrophenoxy)methyl]-4-(2-pyrimidinyl)-1-piperazineethanol dihydrochloride (1.32 g, 3.68 mmol) was hydrogenated in a Parr reactor using 5% Pd/C (0.198 g, 15% by wt) in ethyl acetate (40 mL). After 5 hours, the mixture was filtered through solka floc and the filtrate was concentrated to afford 1.2 g (100%) of product as a pale oil of sufficient purity for use in the next step.

Provenance & Evidence