HCID 20068637, compound → HCID 15723691, compound

HRID 981896Notes

Reaction equation

HRID 981896 reaction equation
Cl.Cl.[N+:3]([C:6]1[CH:28]=[CH:27][C:9]([O:10][CH2:11][CH:12]([OH:26])[CH2:13][N:14]2[CH2:19][CH2:18][N:17]([C:20]3[N:25]=[CH:24][CH:23]=[CH:22][N:21]=3)[CH2:16][CH2:15]2)=[CH:8][CH:7]=1)([O-])=O>C(OCC)(=O)C.[Pd]>[NH2:3][C:6]1[CH:7]=[CH:8][C:9]([O:10][CH2:11][CH:12]([OH:26])[CH2:13][N:14]2[CH2:19][CH2:18][N:17]([C:20]3[N:21]=[CH:22][CH:23]=[CH:24][N:25]=3)[CH2:16][CH2:15]2)=[CH:27][CH:28]=1

Participants

4

Reactant 1

HCID 20068637HCID 20068637, compound

Product 1

HCID 15723691HCID 15723691, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

α-[(4-Nitrophenoxy)methyl]-4-(2-pyrimidinyl)-1-piperazineethanol dihydrochloride (1.32 g, 3.68 mmol) was hydrogenated in a Parr reactor using 5% Pd/C (0.198 g, 15% by wt) in ethyl acetate (40 mL). After 5 hours, the mixture was filtered through solka floc and the filtrate was concentrated to afford 1.2 g (100%) of product as a pale oil of sufficient purity for use in the next step.

Workup

  1. filtrationthe mixture was filtered through solka floc
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-62054adfa09c41a3869763b126881abc
Source dataset
uspto-grants-1991_02
Patent number
US04994459

Reaction notes

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