2,4-Difluorophenyl isocyanate → HCID 53804328, compound

HRID 981903Notes

Reaction equation

HRID 981903 reaction equation
[CH2:1]([NH:8][CH2:9][CH:10]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:23][C:24]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:25]=1[N:31]=[C:32]=[O:33]>C(OCC)(=O)C>[F:23][C:24]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:25]=1[NH:31][C:32](=[O:33])[N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:9][CH:10]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 5932582,4-Difluorophenyl isocyanateHCID 15517254HCID 15517254, compound

Product 1

HCID 53804328HCID 53804328, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of N-benzyl-2,2-diphenyl ethyl amine (1.5 g, 0.005 mol) in 100 mL ethyl acetate was added 2,4-difluorophenyl isocyanate (0.8 g, 0.005 mol). The mixture was stirred for 20 hours at room temperature and then concentrated under vacuum. The residue was taken up in hexane. The solid suspension was filtered and oven-dried, affording 2.2 g of a fine white powder, mp 120-123° C.

Workup

  1. concentrationconcentrated under vacuum
  2. filtrationThe solid suspension was filtered
  3. customoven-dried

Sources & evidence

ORD record
ord-85cdf57222c944658c7b992002c8bec8
Source dataset
uspto-grants-1991_02
Patent number
US04994465

Reaction notes

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