Ammonium Chloride → HCID 9795016, compound

HRID 981922Notes

Reaction equation

HRID 981922 reaction equation
C([O:3][C:4](=O)[CH2:5][O:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:20]=1[C:19]([NH2:21])=[C:18]1[C:13]([CH2:14][CH2:15][CH2:16][CH2:17]1)=[N:12]2)C.CC(C)([O-])C.[K+].[Cl-].[NH4+]>O1CCCC1>[NH:21]1[C:19]2=[C:18]3[C:13](=[N:12][C:11]4=[CH:10][CH:9]=[CH:8][C:7](=[C:20]24)[O:6][CH2:5][C:4]1=[O:3])[CH2:14][CH2:15][CH2:16][CH2:17]3

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 20068607Ethyl[(9-amino-1,2,3,4-tetrahydroacridin-8-yl)oxy]acetateHCID 23665647Potassium tert-butoxide

Product 1

HCID 9795016HCID 9795016, compoundYield 82.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl[(9-amino-1,2,3,4-tetrahydroacridin-8-yl)oxy]acetate (14.50 g) was dissolved in dry tetrahydrofuran (350 ml) and potassium t-butoxide (6.0 g) was added. After stirring for 1 hr, 100 ml saturated ammonium chloride solution (100 ml) was added, and stirring was continued for 30 min. The reaction mixture was evaporated under reduced pressure. The solid was collected and washed with water to give 10.15 g (82.65%) of product, mp 201°-202° C.

Workup

  1. stirringstirring
  2. waitwas continued for 30 min
  3. customThe reaction mixture was evaporated under reduced pressure
  4. customThe solid was collected
  5. washwashed with water

Sources & evidence

ORD record
ord-02b77890b806423999df7c807a01f23d
Source dataset
uspto-grants-1991_02
Patent number
US04994452

Reaction notes

Loading…