Furfurylamine → HCID 2725579, compound

HRID 982038Notes

Reaction equation

HRID 982038 reaction equation
F[C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[O:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[CH2:19][NH2:20]>C(O)C>[O:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[CH2:19][NH:20][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 3438FurfurylamineHCID 2809972-Fluoro-5-nitrobenzoic acid

Product 1

HCID 2725579HCID 2725579, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 14.7 g of 2-fluoro-5-nitrobenzoic acid and 23.1 g of 2-furylmethylamine in 250 ml of ethanol is boiled under a reflux condenser for 6 hours. After the solvent has been removed by distillation under reduced pressure, the residue is dissolved in 150 ml of water, the pH is adjusted to approximately 2 with 2 N HCl, and the precipitate is filtered off. After the precipitate has been washed several times with water, it is dried in a stream of air. Pale yellow crystals, melting point 190°-192° C. (from isopropanol).

Workup

  1. customAfter the solvent has been removed by distillation under reduced pressure
  2. dissolutionthe residue is dissolved in 150 ml of water
  3. filtrationthe precipitate is filtered off
  4. washAfter the precipitate has been washed several times with water, it
  5. customis dried in a stream of air

Sources & evidence

ORD record
ord-ced5c061a53041e884ec7ed5ae5ab7d4
Source dataset
uspto-grants-1991_02
Patent number
US04994493

Reaction notes

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