反应详情

A suspension of 1-aminomethyl-5-hydroxy-3-phenyl-3,4-dihydronaphthalene formic acid salt, the product of Example 2, in acetic anhydride saturated with anhydrous hydrogen chloride is stirred at ambient temperature for 48 h. A solid is collected by filtration and washed with diethyl ether. Crystallization of the crude material is achieved by dissolving the powder in hot ethanol, adding water, filtering the solution hot and allowing it to cool. Filtration and drying of the solid collected affords 1-aminomethyl-5-acetoxy-3-phenyl-3,4dihydronaphthalene hydrochloride.

1. filtrationA solid is collected by filtration
2. washwashed with diethyl ether
3. customCrystallization of the crude material
4. dissolutionby dissolving the powder in hot ethanol
5. additionadding water
6. filtrationfiltering the solution hot
7. temperatureto cool
8. filtrationFiltration
9. customdrying of the solid
10. customcollected