反应详情

In 30 ml of phosphorus oxychloride is suspended 5.0 g of 2-chloroimidazo[1,2-a]pyridine-3-sulfonic acid and the suspension is refluxed for 5 hours. After cooling, the reaction mixture is poured in 250 ml of ice-water and extracted with dichloromethane. The dichloromethane layer is separated and dried over anhydrous sodium sulfate and the dichloromethane is distilled off under reduced pressure to give 4.6 g of the title compound as pale yellow crystals.

1. temperaturethe suspension is refluxed for 5 hours
2. temperatureAfter cooling
3. extractionextracted with dichloromethane
4. customThe dichloromethane layer is separated
5. dry with materialdried over anhydrous sodium sulfate
6. distillationthe dichloromethane is distilled off under reduced pressure